135412-61-2

Upstream product

• 70679-89-9 4-acetoxy-3-chlorobenzoic acid 
• 3964-58-7 3-chloro-4-hydroxybenzoic acid 

Downstream Products

• 1415574-49-0 2-chloro-4-(8-methyl-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)phenyl acetate 
• 1415574-54-7 3-chloro-4-hydroxy-N-(8-methyl-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-yl)benzamide 

Relevant academic research and scientific papers

A Tandem Ring Opening/Closure Reaction in A BF3-Mediated Rearrangement of Spirooxindoles

Treatment of the readily accessible spiro-cyclohexadienones from the PhI(OCOCF3)2-mediated spiro-cyclization of N-substituted benzanilides, with BF3?Et2O initiates a tandem ring opening/closure reaction leading to the formation of the biologically interesting 8-hydroxy-phenanthridin-6(5H)-one compounds. This unique rearrangement pattern involves the ‘migration’ of the electron-deficient N-methyl carbamoyl moiety rather than the electron-rich aryl group as observed and reported previously in all other similar transformations. (Figure presented.).

3D-QSAR-assisted design, synthesis, and evaluation of novobiocin analogues

Hsp90 is an attractive therapeutic target for the treatment of cancer. Extensive structural modifications to novobiocin, the first Hsp90 C-terminal inhibitor discovered, have produced a library of novobiocin analogues and revealed some structure-activity relationships. On the basis of the most potent novobiocin analogues generated from prior studies, a three-dimensional quantitative structure-activity (3D QSAR) model was built. In addition, a new set of novobiocin analogues containing various structural features supported by the 3D QSAR model were synthesized and evaluated against two breast cancer cell lines. Several new inhibitors produced antiproliferative activity at midnanomolar concentrations, which results through Hsp90 inhibition.