135414-03-8

Basic information

• Product Name: 2-TERT-BUTOXYCARBONYLAMINO-3-(4-CYANO-PHENYL)-PROPIONIC ACID
• Synonyms: 2-TERT-BUTOXYCARBONYLAMINO-3-(4-CYANO-PHENYL)-PROPIONIC ACID;BOC-DL-4-CYANOPHENYLALANINE;4-Cyano-N-Boc-DL-phenylalanine;2-((tert-butoxycarbonyl)amino)-3-(4-cyanophenyl)propanoic acid(WXC06818)
• CAS NO: 135414-03-8
• Molecular Formula: C₁₅H₁₈N₂O₄
• Molecular Weight: 290.31
• Mol File: 135414-03-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-TERT-BUTOXYCARBONYLAMINO-3-(4-CYANO-PHENYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-TERT-BUTOXYCARBONYLAMINO-3-(4-CYANO-PHENYL)-PROPIONIC ACID(135414-03-8)
• EPA Substance Registry System: 2-TERT-BUTOXYCARBONYLAMINO-3-(4-CYANO-PHENYL)-PROPIONIC ACID(135414-03-8)

Safety Data

• Hazardous Substances Data: 135414-03-8(Hazardous Substances Data)

Usage

General Description

2-TERT-BUTOXYCARBONYLAMINO-3-(4-CYANO-PHENYL)-PROPIONIC ACID is a compound with the chemical formula C16H20N2O4. It is a derivative of 3-(4-cyano-phenyl)-propionic acid and is often used as a chemical intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-TERT-BUTOXYCARBONYLAMINO-3-(4-CYANO-PHENYL)-PROPIONIC ACID contains a tert-butoxycarbonyl (Boc) protecting group, which is commonly used in organic synthesis to protect amines from unwanted reactions. 2-TERT-BUTOXYCARBONYLAMINO-3-(4-CYANO-PHENYL)-PROPIONIC ACID is also known for its potential as a building block in the development of new drugs and can be utilized in various chemical reactions to produce a range of biologically active compounds.

Upstream product

• 773837-37-9 sodium cyanide 
• 103882-09-3 N-Boc-DL-4-iodophenylalanine 
• 1991-81-7 p-iodophenylalanine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 18910-26-4 2-amino-3-(4-cyano-phenyl)-propionic acid 
• 246514-80-7 4-cyano-phenylalanine methyl ester 
• 4530-20-5 BOC-glycine 
• 17201-43-3 4-cyanobenzyl bromide 

Downstream Products

• 177031-15-1 N^α-tert-Butoxycarbonyl-p-hydroxyamidino-D,L-phenylalanine tert-butyl ester 
• 1606181-24-1 2-((tert-butoxycarbonyl)amino)-3-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl)propanoic acid 
• 1606181-26-3 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl)propanoic acid 
• 1606181-25-2 2-amino-3-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl)prapanoic acid 
• 131668-25-2 (S)-2-((S)-3-tert-Butoxycarbonyl-2-{2-[2-tert-butoxycarbonylamino-3-(4-thiocarbamoyl-phenyl)-propionylamino]-acetylamino}-propionylamino)-3-methyl-butyric acid tert-butyl ester 
• 177031-14-0 N^α-tert-Butoxycarbonyl-p-cyano-D,L-phenylalanine tert-butyl ester 
• 131668-24-1 Boc-D,L-p-cyano-Phe-Gly-Asp(O-t-Bu)-Val-O-t-Bu 

Relevant articles and documents

Photoinduced Copper(I)-Catalyzed Cyanation of Aromatic Halides at Room Temperature

The first photoinduced copper(I)-catalyzed cyanation of aromatic halides at room temperature has been developed. The sp2 cyanation reaction exhibits outstanding tolerance to functional groups including primary amines and carboxylic acids, and chemoselectivity to SN2-reactive alkyl chlorides. Mechanistic investigations indicate that the reaction occurs via a single-electron transfer (SET) between the aryl halide and an excited copper(I) cyanide catalytic intermediate. (Figure presented.).

12-EPI-PLEUROMUTILINS

A compound selected from 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-sulfanyl)-acetyl]-12-epi-mutilins, or 14-0-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-oxy)-acetyl]-12-epi-mutilins, wherein 12-epi-mutilin is characterized in that the mutilin ring at position 12 is substituted by two substituents, the first substituent at position 12 of the mutilin ring is a methyl group which methyl group has the inverse stereochemistry compared with the stereochemistry of the methyl group at position 12 of the naturally occurring pleuromutilin ring, the second substituent at position 12 of the mutilin ring is a hydrocarbon group comprising at least one nitrogen atom and all other substituents of the mutilin ring having the same stereochemistry compared with the stereochemistry of the substituents at the corresponding positions in the naturally occurring pleuromutilin ring; optionally in the form of a salt and/or solvate, wherein the naturally occurring pleuromutilin is of formula PLEU, processes for the preparation of such compounds and their use as pharmaceuticals.