135416-43-2

Basic information

• Product Name: CAINDEXNAME:8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC
• Synonyms: CAINDEXNAME:8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC;(()-2-beta-Carbomethoxy-3-beta-(4-iodophenyl)tropane;8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-iodophenyl)-8-methyl, methyl ester, (1R,2S,3S,5S)-;(1R,2S,3S,5S)-3-(4-Iodophenyl)tropane-2-carboxylic acid methyl ester;(1R,2S,3S,5S)-8-Methyl-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester;(1R,5S)-2β-Methoxycarbonyl-3β-(4-iodophenyl)tropane;(1R,5S)-3β-(4-Iodophenyl)tropane-2β-carboxylic acid methyl ester;(1β,5β)-3β-(4-Iodophenyl)tropane-2β-carboxylic acid methyl ester
• CAS NO: 135416-43-2
• Molecular Formula: C₁₆H₂₀INO₂
• Molecular Weight: 385.24
• Mol File: 135416-43-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 405.3 °C at 760 mmHg
• Flash Point: 198.9 °C
• Appearance: /
• Density: 1.493 g/cm⁴⁸
• CAS DataBase Reference: CAINDEXNAME:8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC(CAS DataBase Reference)
• NIST Chemistry Reference: CAINDEXNAME:8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC(135416-43-2)
• EPA Substance Registry System: CAINDEXNAME:8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC(135416-43-2)

Safety Data

• Hazardous Substances Data: 135416-43-2(Hazardous Substances Data)

Usage

Chemical Properties

Colourless to yellowish crystals

InChI:InChI=1/C16H20INO2/c1-18-12-7-8-14(18)15(16(19)20-2)13(9-12)10-3-5-11(17)6-4-10/h3-6,12-15H,7-9H2,1-2H3/t12-,13+,14+,15-/m0/s1

Upstream product

• 17878-43-2 [4-(trimethylsilyl)phenyl]magnesium bromide 
• 50-36-2 Cocaine 
• 127279-73-6 3β-(4-nitrophenyl)tropane-2β-carboxylic acid methyl ester 
• 50370-54-2 3β-phenyltropane-2β-carboxylic acid methyl ester 
• 50373-10-9 (R)-(-)-anhydroecgonine methyl ester 
• 134052-62-3 3β-(4-aminophenyl)tropane-2β-carboxylic acid methyl ester 
• 481-37-8 ecgonine 
• 50373-10-9 methyl ecgonidine 
• 174224-35-2 2β-carbomethoxy-3β-(4'-trimethylsilylphenyl)tropane 
• 50372-80-0 WIN 35,065-2 

Downstream Products

• 136794-87-1 (1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester 
• 136794-86-0 C₁₆H₂₀⁽¹²³⁾INO₂ 
• 141807-58-1 RTI 102 
• 238411-13-7 (1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 
• 303731-69-3 (1R,2S,3S,5S)-8-Methyl-3-(4-trimethylsilanylethynyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester 
• 156496-01-4 (1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester 
• 136794-88-2 [2β-carbomethoxy-3β-(4-tributylstannylphenyl)tropane] 
• 181796-44-1 2β-carbomethoxy-3β-(4'-isopropylphenyl)tropane 
• 181796-54-3 3β-(4'-propynylphenyl)nortropane-2β-carboxylic acid methyl ester 
• 181796-45-2 2β-carbomethoxy-3β-(4'-n-propylphenyl)tropane 
• 181796-55-4 3β-(4'-propylphenyl)nortropane-2β-carboxylic acid methyl ester 
• 181796-46-3 3β-(4'-isopropylphenyl)nortropane-2β-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: Potential positron emission tomography (PET) imaging agents for the dopamine transporter

A series of novel fluoroalkyl-containing tropane derivatives was synthesized, and their binding affinities for the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET) were determined via competitive binding assays. Among these derivatives, the fluoropropyl ester of β-CIT (19), the fluoroethyl ester of β-CIT (20), the N-fluoropropyl derivative of β-CBT (12), and the fluoropropyl ester of β-CMT (18) displayed higher affinity and greater selectivity for the DAT versus SERT and NET than FP-CIT, which indicates that they are attractive candidates for the development of 18F-labeled PET imaging agents for the DAT.

LABELED COCAINE ANALOGS

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COCAINE RECEPTOR BINDING LIGANDS

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