135423-85-7

Basic information

• Product Name: 10-propargyl-5-methyl-5-deazaaminopterin analog of folic acid
• Synonyms: 10-propargyl-5-methyl-5-deazaaminopterin analog of folic acid
• CAS NO: 135423-85-7
• Molecular Formula: C₂₄H₂₅N₇O₅
• Molecular Weight: 491.4992
• Mol File: 135423-85-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.464g/cm³
• Refractive Index: 1.721
• CAS DataBase Reference: 10-propargyl-5-methyl-5-deazaaminopterin analog of folic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 10-propargyl-5-methyl-5-deazaaminopterin analog of folic acid(135423-85-7)
• EPA Substance Registry System: 10-propargyl-5-methyl-5-deazaaminopterin analog of folic acid(135423-85-7)

Safety Data

• Hazardous Substances Data: 135423-85-7(Hazardous Substances Data)

Usage

Chemical structure

A synthetic compound structurally similar to folic acid, a vitamin essential for cell growth and division.

Design purpose

Mimic the function of folic acid in the body to target cancer cells while minimizing impact on healthy cells.

Target

Disrupts the growth of cancer cells by targeting the same pathways as folic acid.

Potential use

Studied for its potential application in cancer treatment.

Research status

Ongoing research to better understand its therapeutic applications, safety, and efficacy for medical use.

Mechanism of action

The compound may interfere with the synthesis of nucleic acids and proteins in cancer cells, leading to cell death.

Advantages

May have fewer side effects on normal cells compared to traditional chemotherapy drugs.

Challenges

Further research is needed to optimize the compound's properties and ensure its safety and effectiveness.

Synthesis

The analog is synthesized through chemical reactions, involving the modification of the folic acid structure.

Future directions

Continued research may lead to the development of new drugs targeting cancer cells more effectively and with fewer side effects.

InChI:InChI=1/C24H25N7O5/c1-3-10-31(12-15-11-27-21-19(13(15)2)20(25)29-24(26)30-21)16-6-4-14(5-7-16)22(34)28-17(23(35)36)8-9-18(32)33/h1,4-7,11,17H,8-10,12H2,2H3,(H,28,34)(H,32,33)(H,35,36)(H4,25,26,27,29,30)/t17-/m0/s1

Upstream product

• 101810-75-7 6-(bromomethyl)-2,4-diamino-5-methylpyrido<2,3-d>pyrimidine dihydrobromide 
• 101810-73-5 2,4-diamino-5-methylpyrido<2,3-d>pyrimidine-6-carbonitrile 
• 101348-31-6 2,4-diamino-6-(hydroxymethyl)-5-methylpyrido<2,3-d>pyrimidine 
• 101810-74-6 2,4-diamino-5-methylpyrido<2,3-d>pyrimidine-6-carboxaldehyde 
• 76858-72-5 diethyl N-(4-(prop-2-ynylamino)benzoyl)-L-glutamate 
• 137141-86-7 10-propargyl-5-methyl-5-deazaaminopterin diethyl ester 

Relevant articles and documents

Synthesis and Antifolate Evaluation of the 10-Propargyl Derivatives of 5-Deazafolic Acid, 5-Deazaaminopterin, and 5-Methyl-5-deazaaminopterin

5-Deaza-10-propargylfolic acid (4), an analogue of the thymidylate synthase (TS) inhibitor 10-propargyl-5,8-dideazafolic acid (PDDF, 1), was prepared via alkylation of diethyl N--L-glutamate (7) by 2-amino-6-(bromomethyl)-4(3H)-