135427-08-6

Basic information

• Product Name: 4-Fluoro-3-methylbenzaldehyde
• Synonyms: 4-FLUORO-3-METHYLBENZALDEHYDE;4-FLUORO-M-TOLUALDEHYDE;4-Fluoro-3-methylbenzaldehyde, 97+%;Benzaldehyde, 4-fluoro-3-methyl- (9CI);4-Fluoro-m-tolualdehyde, 2-Fluoro-5-formyltoluene
• CAS NO: 135427-08-6
• Molecular Formula: C₈H₇FO
• Molecular Weight: 138.14
• EINECS: -0
• Product Categories: Fluorin-contained benzaldehyde series;ALDEHYDE;Benzaldehyde;Miscellaneous;Aldehydes;C8;Carbonyl Compounds;Aryl Fluorinated Building Blocks;Building Blocks;C7-C8;Carbonyl Compounds;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Fluorine series
• Mol File: 135427-08-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 208 °C(lit.)
• Flash Point: 79 °C
• Appearance: /
• Density: 1.132 g/mL at 25 °C(lit.)
• Vapor Pressure: 5.16E-06mmHg at 25°C
• Refractive Index: n20/D 1.522(lit.)
• Storage Temp.: Refrigerator (+4°C)
• Water Solubility: Slightly soluble in water.
• Sensitive: Air Sensitive
• BRN: 4797794
• CAS DataBase Reference: 4-Fluoro-3-methylbenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-3-methylbenzaldehyde(135427-08-6)
• EPA Substance Registry System: 4-Fluoro-3-methylbenzaldehyde(135427-08-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 135427-08-6(Hazardous Substances Data)

Usage

Chemical Properties

yellow-greenish liquid or low melting solid

Uses

4-Fluoro-3-methylbenzaldehyde is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dye stuff field.

InChI:InChI=1/C11H7F3N2O4/c1-20-10(17)8(5-15)7-3-2-6(11(12,13)14)4-9(7)16(18)19/h2-4,8H,1H3

Upstream product

• 13061-96-6 dihydroxy-methyl-borane 
• 77771-02-9 3-bromo-4-fluorobenzaldehyde 
• 51437-00-4 5-bromo-2-fluorotoluene 
• 122-51-0 orthoformic acid triethyl ester 
• 716344-13-7 trifluoromethanesulfonic acid 4-formyl-2-methylphenyl ester 
• 95-52-3 2-Fluorotoluene 
• 201230-82-2 carbon monoxide 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 370867-83-7 tert-butyl (E)-3-(3-fluoro-4-methylphenyl)acrylate 
• 959653-14-6 1-[2-(4-{[(4-fluoro-3-methylphenyl)methyl]amino}-1-piperidinyl)ethyl]-7-(methyloxy)-1,5-naphthyridin-2(1H)-one 
• 1100154-96-8 3-(1,3-dioxolan-2-yl)-1-(4-fluoro-3-methylphenyl)propan-1-ol 
• 1350829-42-3 C₈₃H₁₃₁FN₁₄O₁₆ 
• 1380584-30-4 1-(2-amino-ethyl)-6-hydroxy-2-oxo-4-(4-fluoro-3-methylphenyl)-1,2-dihydropyridine-3,5-dicarbonitrile 
• 1193512-31-0 C₁₈H₂₈FNO₂ 
• 1189358-62-0 C₁₅H₁₃FN₄O 
• 1170614-31-9 (1E,3E)-1-(4-fluoro-3-methylphenyl)-2-methylpent-1-en-3-one oxime 
• 878662-28-3 ethyl 3-(4'-fluoro-3'-methylphenyl)-2-propenoate 
• 1043453-95-7 8-(4-fluoro-3-methylphenyl)oct-7-enoic acid 
• 1043450-52-7 (E)-Methyl 3-(4-fluoro-3-methylphenyl)acrylate 
• 521266-99-9 (2S)-1-({2-[2-(4-Fluoro-3-methyl-phenyl)-5-methyl-oxazol-4-yl]-1,1-dimethyl-ethylamino}-acetyl)-pyrrolidine-2-carbonitrile 
• 521267-03-8 (2S)1-({1-[2-(4-Fluoro-3-methyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-cyclopropylamino}-acetyl)-pyrrolidine-2-carbonitrile 
• 543731-47-1 4-Fluoro-3-methyl-benzaldehyde O-methyl-oxime 

Relevant articles and documents

A Fluorinated Ligand Enables Room-Temperature and Regioselective Pd-Catalyzed Fluorination of Aryl Triflates and Bromides

A new biaryl monophosphine ligand (AlPhos, L1) allows for the room-temperature Pd-catalyzed fluorination of a variety of activated (hetero)aryl triflates. Furthermore, aryl triflates and bromides that are prone to give mixtures of regioisomeric aryl fluorides with Pd-catalysis can now be converted to the desired aryl fluorides with high regioselectivity. Analysis of the solid-state structures of several Pd(II) complexes, as well as density functional theory (DFT) calculations, shed light on the origin of the enhanced reactivity observed with L1.

Piperazine derivatives

This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.

Process for preparing benzyl alcohols and their use

Benzyl alcohols, particularly those which bear fluorine substituents or fluoroalkyl substituents on the benzyl ring, can be obtained by formylation of corresponding aryl bromides to form benzaldehydes and reduction of the latter using further formate, wherein the benzaldehydes formed do not have to be isolated.