1354363-84-0

Basic information

• Product Name: 3,8-bis(benzyloxy)-6,6-dimethyl-6H-benzo[c]chromene
• Synonyms: 3,8-bis(benzyloxy)-6,6-dimethyl-6H-benzo[c]chromene
• CAS NO: 1354363-84-0
• Molecular Weight: 422.524
• Mol File: 1354363-84-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,8-bis(benzyloxy)-6,6-dimethyl-6H-benzo[c]chromene(CAS DataBase Reference)
• NIST Chemistry Reference: 3,8-bis(benzyloxy)-6,6-dimethyl-6H-benzo[c]chromene(1354363-84-0)
• EPA Substance Registry System: 3,8-bis(benzyloxy)-6,6-dimethyl-6H-benzo[c]chromene(1354363-84-0)

Safety Data

• Hazardous Substances Data: 1354363-84-0(Hazardous Substances Data)

Upstream product

• 85604-06-4 5-(benzyloxy)-2-bromobenzaldehyde 
• 105805-16-1 1-[2-bromo-5-(phenylmethoxy)phenyl]ethanone 
• 1354364-21-8 2-[5-(benzyloxy)-2-bromophenyl]propan-2-ol 
• 1354364-52-5 1-[5-(benzyloxy)-2-bromophenyl]ethanol 

Relevant articles and documents

A domino palladium-catalyzed C-C and C-O bonds formation via dual O-H bond activation: Synthesis of 6,6-dialkyl-6 H -benzo[ c ]chromenes

An efficient Pd-catalyzed domino reaction of α,α-dialkyl-(2- bromoaryl)methanols to 6,6-dialkyl-6H-benzo[c]chromenes is presented. Their formation can be explained via a five membered Pd(II)-cycle that efficiently involves a domino homocoupling with the second molecule, β-carbon cleavage, and finally intramolecular Buchwald-Hartwig cyclization. This domino process effectively involves breaking of five σ-bonds (2C-Br, 2O-H, and a C-C) and formation of two new σ-bonds (C-C and C-O). This mechanistic pathway is unprecedented and further illustrates the power of transition metal catalysis.