135446-25-2Relevant academic research and scientific papers
Synthesis and antimicrobial activity of 4-amino trinems
Tranquillini, Maria Elvira,Araldi, Gian Luca,Donati, Daniele,Pentassuglia, Giorgio,Pezzoli, Anna,Ursini, Antonella
, p. 1683 - 1688 (2007/10/03)
This article deals with the study carried out on the synthesis of 4-amino substituted trinems 1 starting from the key-intermediate (3S, 4R)-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-4-[(1'R, 2'S, 3'R)-1',2'-epoxycyclohex-3'-yl]azetidin-2-one 2. In particular, epoxide opening with various amines and subsequent cyclization to the corresponding trinems were explored. Their synthesis and antimicrobial activity are reported.
