1354483-36-5

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1354483-33-2 (1R)-1-C-allyl-N-(tert-butoxycarbonyl)-2,3,4-tri-O-benzyl-1,5-dideoxy-1,5-imino-D-xylitol 
• 19300-54-0 toluene-4-sulfonic acid pent-4-enyl ester 
• 1354483-30-9 (1R)-1-C-allyl-N-naphth-2-ylmethyl-2,3,4-tri-O-benzyl-1,5-dideoxy-1,5-imino-D-xylitol 
• 1354483-32-1 (1R)-1-C-allyl-2,3,4-tri-O-benzyl-1,5-dideoxy-1,5-imino-D-xylitol 

Relevant academic research and scientific papers

Synthesis of azide-armed α-1-C-alkyl-imino-d-xylitol derivatives as key building blocks for the preparation of iminosugar click conjugates

Azide-armed α-1-C-alkyl-imino-d-xylitol derivatives have been efficiently prepared by way of olefin cross-metathesis in eight to nine steps and in an overall yield of 19% to 26% from 2,3,4-tri-O-benzyl-d-xylopyranose. Optimization of cleavage conditions of N-NAP-protected tertiary amines using DDQ in CH2Cl2-H2O (18:1) is also reported. The iminosugars synthesized will be used as key building blocks in the synthesis of multivalent iminosugars of biological interest by way of Cu(I)-catalyzed azide-alkyne cycloaddition reaction.