135449-26-2Relevant academic research and scientific papers
Heterocyclization of Acetamidrazones. I. Synthesis of 1,2,4-Triazolopyridines via Ring Closure of 6-(2-Acylhydrazino)pyridine Intermediates
Cocco, Maria Teresa,Congiu, Cenzo,Onnis, Valentina,Maccioni, Antonio
, p. 797 - 800 (2007/10/02)
The reaction of N1-acyl-2-ethoxycarbonylacetamidrazones with ethoxymethylenecyanoacetate (EMCA) has been examined.The acetamidrazone 1a reacts with EMCA in boiling dimethyl sulphoxide to give the 1,2,4-triazolopyridin-3(2H)-one 2 in excellent yield.Similarly from the amidrazones 1b-h the 1,2,4-triazolopyridines 3b-h were obtained.When the reaction between the amidrazones and EMCA was performed in ethanolic solution, the 6-(2-acylhydrazino)pyridines 4 were isolated.Ring closure of 4 afforded the 1,2,4-triazolopyridines.
