1354546-78-3Relevant articles and documents
Potent inhibitors of LpxC for the treatment of gram-negative infections
Brown, Matthew F.,Reilly, Usa,Abramite, Joseph A.,Arcari, Joel T.,Oliver, Robert,Barham, Rose A.,Che, Ye,Chen, Jinshan Michael,Collantes, Elizabeth M.,Chung, Seung Won,Desbonnet, Charlene,Doty, Jonathan,Doroski, Matthew,Engtrakul, Juntyma J.,Harris, Thomas M.,Huband, Michael,Knafels, John D.,Leach, Karen L.,Liu, Shenping,Marfat, Anthony,Marra, Andrea,McElroy, Eric,Melnick, Michael,Menard, Carol A.,Montgomery, Justin I.,Mullins, Lisa,Noe, Mark. C.,O'Donnell, John,Penzien, Joseph,Plummer, Mark S.,Price, Loren M.,Shanmugasundaram, Veerabahu,Thoma, Christy,Uccello, Daniel P.,Warmus, Joseph S.,Wishka, Donn G.
, p. 914 - 923 (2012/03/27)
In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid 1a.
