1354575-46-4

Upstream product

• 15466-96-3 3-isobutoxy-5,5-dimethylcyclohex-2-en-1-one 
• 126-81-8 dimedone 
• 305837-95-0 4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide 

Downstream Products

• 1370511-66-2 (Z)-4-(chloro(phenyl)methylene)-9,9-dimethyl-2-tosyl-2-azaspiro[4.5]dec-6-ene 
• 1404440-36-3 N-(3-(4-bromophenyl)prop-2-yn-1-yl)-N-((3-((tert-butyldimethylsilyl)oxy)cyclohex-1-en-1-yl)methyl)-4-methylbenzenesulfonamide 
• 1404440-17-0 (Z)-4-(chlorophenylmethylene)-10,10-dimethyl-2-tosyl-2-azaspiro[4.6]undec-7-ene 
• 1404440-51-2 (Z)-4-((4-bromophenyl)iodomethylene)-2-tosyl-2-azaspiro[4.6]undec-7-ene 
• 1354574-90-5 9-benzoyl-3,3-dimethyl-7-tosyl-7-azaspiro[4.5]dec-9-en-1-one 
• 1354575-10-2 C₂₅H₂₉NO₄S 

Relevant academic research and scientific papers

Synthesis of 2-azaspiro[4.6]undec-7-enes from N -tosyl- N -(3-arylpropargyl)-tethered 3-methylcyclohex-2-en-1-ols

The FeCl3-promoted synthesis of 2-azaspiro[4.6]undec-7-ene rings proceeds via ring expansion/cyclization/chlorination of N-tosyl-N-(3- arylpropargyl)-tethered 6-methylbicyclo[4.1.0]heptan-2-ols. This azaspirocyclic ring skeleton can also be obtained in one pot from the tert-butyldimethylsilyl- protected N-tosyl-N-(3-arylpropargyl)-tethered 3-methylcyclohex-2-en-1-ols and diethylzinc/diiodomethane.

Facile synthesis of azaspirocycles via iron trichloride-promoted cyclization/chlorination of cyclic 8-Aryl-5-aza-5-tosyl-2-en-7-yn-1-ols

A simple and efficient FeCl3-promoted cyclization/chlorination of cyclic tosylamine-tethered 8-aryl-2-en-7-yn-1-ols was observed. The reaction proceeded instantaneously at 23 °C in air to afford (Z)-4- (arylchloromethylene)-substituted azaspiro