1354636-84-2Relevant academic research and scientific papers
Highly efficient and stereoselective construction of dispiro-[oxazolidine- 2-thione]bisoxindoles and dispiro[imidazolidine-2-thione]bisoxindoles
Han, Yan-Yan,Chen, Wen-Bing,Han, Wen-Yong,Wu, Zhi-Jun,Zhang, Xiao-Mei,Yuan, Wei-Cheng
supporting information; experimental part, p. 490 - 493 (2012/03/26)
An efficient and stereoselective reaction between 3-isothiocyanato oxindoles and isatins/isatinimines has been developed to afford structurally diverse dispiro[oxazolidine-2-thione]bisoxindoles and dispiro[imidazolidine-2- thione]bisoxindoles in excellent results under mild conditions. The potential of asymmetric induction by means of a chiral auxiliary was explored. The isomers are separable, and products could be isolated as single diastereomers by column chromatography. Further synthetic transformations of the reaction product were also successfully realized.
