1354644-15-7

Basic information

• Product Name: C₁₆H₂₄ClNO₃
• Synonyms: C₁₆H₂₄ClNO₃
• CAS NO: 1354644-15-7
• Molecular Weight: 313.824
• Mol File: 1354644-15-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₂₄ClNO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₂₄ClNO₃(1354644-15-7)
• EPA Substance Registry System: C₁₆H₂₄ClNO₃(1354644-15-7)

Safety Data

• Hazardous Substances Data: 1354644-15-7(Hazardous Substances Data)

Upstream product

• 72-18-4 L-valine 
• 2420-26-0 4-chlorosalicylaldehyde 
• 13518-40-6 L-valine tert-butylester hydrochloride 

Relevant articles and documents

Effect of substituents on enantioselectivity in chiral oxazaborolidine mediated asymmetric ketone reduction reaction

Various new chiral ligands have been synthesized by the condensation of different esters of L-Valine with different substituted salicylaldehydes in order to find the most effective catalyst for the enantioselctive ketone reduction. Chiral amine synthesized from L-Valine methyl ester and 5-chloro salicylaldehyde is found to catalyse the enantioselective reduction of prochiral ketone with high yield (99%) and enantiomeric excess (91%) with 20 mol% of the catalyst using borane dimethylsulphide as a stoichiometric reducutant. Different subsituted prochiral ketones have also been reduced in high yield upto 90% and the corresponding secondary alcohols are formed with good enantiomeric excess upto 99%. The mechanism of this reduction can be very well explained by considering a plausible mechanism for the CBS catalyst.