1354657-75-2

Upstream product

• 1354657-72-9 1-but-2-ynyloxy-4-methanesulfonylbenzene 
• 14763-60-1 4-methanesulfonyl-phenol 
• 1354657-74-1 tert-butyl {4-[2-(4-but-2-ynyloxybenzenesulfonyl)-1-hydroxyethyl]benzyl}carbamate 
• 1354657-73-0 tert-butyl {4-[2-(4-but-2-ynyloxybenzenesulfonyl)acetyl]benzyl}carbamate 

Downstream Products

• 1354657-76-3 4-[(E)-2-(4-But-2-ynyloxybenzenesulfonyl)vinyl]benzylamine hydrochloride 
• 1354657-77-4 {4-[(E)-2-(4-but-2-ynyloxybenzenesulfonyl)vinyl]benzyl}diethylamine 
• 1354657-78-5 N-[2-(4-but-2-ynyloxybenzenesulfonyl)-1-(4-diethylaminomethylphenyl)ethyl]hydroxylamine 
• 1354657-36-5 N-[2-(4-but-2-ynyloxybenzenesulfonyl)-1-(4-diethylaminomethylphenyl)ethyl]-N-hydroxyformamide 

Relevant academic research and scientific papers

N-HYDROXYFORMAMIDE DERIVATIVE AND MEDICAMENT CONTAINING SAME

A compound represented by the following general formula (I) which has ADAM17 inhibitory activity, or a salt thereof, or a solvate thereof: wherein X represents a phenylene group; Y represents a hydrogen atom, —(CH2)mR1 or the like; R1 represents —NR5COR2, —NR5SO2R2 or —NR3R4; R2 represents a C1-C6 alkyl group, an aryl group, or a C1-C6 alkoxy group; R3 and R4 represent a C1-C6 alkyl group and the like; R5 represents a hydrogen atom or a C1-C6 alkyl group or the like; m indicates an integer of from 0 to 4; and Z represents a hydrogen atom or a C1-C6 alkyl group.

COMPOSITION FOR MAINTAINING FUNCTION OF PLATELETS

A composition for maintaining a function of platelets, the composition comprising, as an active ingredient, a compound represented by the following general formula (I) or a salt thereof, or a solvate thereof: wherein X represents a phenylene group;Y represents any one of a hydrogen atom and —(CH2)mR1;wherein m represents an integer of any one of 0 to 4; andR1 is any one of —NR5COR2, —NR5SO2R2, and —NR3R4;wherein R2 represents any one of a C1 to C6 alkyl group, an aryl group, a C1 to C6 alkoxy group, and the like;R3 and R4 represent a C1 to C6 alkyl group or the like; andR5 represents any one of a hydrogen atom, a C1 to C6 alkyl group, and the like; andZ represents any one of a hydrogen atom and a C1 to C6 alkyl group.