1354694-87-3Relevant academic research and scientific papers
Novel α-amino acid-derived phase-transfer catalyst application to a highly enantio- and diastereoselective nitro-Mannich reaction
Liu, Yuxin,Wei, Zhonglin,Leu, Yu,Cao, Jungang,Liang, Dapeng,Lin, Yingjie,Duan, Haifeng
, p. 9234 - 9242 (2017/11/14)
New quaternary ammonium types of bifunctional asymmetric phase-transfer catalysts bearing multiple hydrogen-bonding donors derived from α-amino acids were readily prepared and found to be highly efficient in the asymmetric nitro-Mannich reactions of amidosulfones. Very broad substrate generality was observed, and the products were achieved in high enantio-/diastereoselectivities (90->99.9% ee, 90:10 to 92:8 dr). Compared with previous reports, the enantioselectivity of aliphatic amidosulfones has been improved to a high level (91-93% ee).
Highly enantioselective nitro-mannich reaction catalyzed by cinchona alkaloids and N-benzotriazole derived ammonium salts
Wei, Yu,He, Wei,Liu, Yulong,Liu, Peng,Zhang, Shengyong
, p. 704 - 707 (2012/04/10)
The catalytic enantio- and diastereoselective nitro-Mannich reaction of α-amido sulfones in the mixed solvent of toluene/H2O has been realized using a phase-transfer catalyst (PTC) derived from cinchona alkaloids and N-benzotriazole. It performed well over a wide range of substrates to give the desired products in good yields (up to 94%) with excellent enantioselectivities (up to 99% ee) and diastereoselectivities (up to 99:1).
