1354717-84-2Relevant academic research and scientific papers
PHYSIOLOGICALLY ACTIVE BIS-DIALKYLAMIDES OF PHOSPHORYL-SUBSTITUTED 1,4-DICARBOXYLIC ACIDS AND METHOD FOR PRODUCING SAME
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Paragraph 0020; 0028, (2013/11/19)
To produce physiologically active bis-dialkylamides of phosphorylated 1,4-dicarboxylic acids of formula (I) wherein each R can be straight or branched alkyl, unsubstituted or substituted phenyl, wherein substituents of the phenyl group can be from 1 to 5 halogen atoms, from 1 to 5 lower alkyl groups, from 1 to 5 lower alkoxy groups, from 1 to 5 dialkylamino groups; R' can be straight or branched alkyl; Y is a direct bond or a methylene group, a mixture of the corresponding phosphorylated 1,4-dicarboxylic acids is heated with hexaalkyl triamidophosphites of general formula (R'2N)3P in an organic solvent within a temperature range from 20 to 80°C until the reaction is complete followed by separation and purification. The compounds of general formula (I) thereby produced possess neuroprotective properties and can be used in medicine.
Physiologically active bis(dialkylamides) of phosphoryl-substituted α,ω-dicarboxylic acids
Yarkevich,Safronova,Petrova,Gabrelyan,Zamoyski,Grigor'Ev,Bachurin,Zefirov
, p. 41 - 45 (2013/03/28)
Bis(dialkylamides) of phosphoryl-substituted α,ω-dicarboxylic acids were synthesized and their biological activity was studied.
