135472-30-9Relevant academic research and scientific papers
Claisen-Kondensation mit ausgewaehlten Dithioestern - Synthese spezieller 3-Methylthio-acrylnitrile
Mayer, R.,Hartenhauer, H.,Gruner, M.
, p. 35 - 40 (2007/10/02)
A useful synthetic route to the mono- and diheteroaryl-3-methyl-acrylonitriles 1 and 2 is demonstrated by the thioanalogous Claisen-condensation.In the presence of sodium hydride in tetrahydrofurane or under PTC-conditions heteroaryl dithiocarboxylic esters 3 react with CH-acidic compounds 4 or 9 to form 3-mercapto-acrylonitriles (e.g. 5).Methylation leads to mono- and diheteroaryl-3-methylthioacrylonitriles 1 and 10 (type 2).In the same manner tetrathioterephthalic ester 6 reacts with two equivalents of CH-acidic compounds yielding 8 and 11.By means of spectroscopic methods, especially 1H- and 13C-n.m.r., the structures of the compounds obtained are confirmed.
