1354789-75-5Relevant academic research and scientific papers
Development of the enantioselective addition of ethyl diazoacetate to aldehydes: Asymmetric synthesis of 1,2-diols
Trost, Barry M.,Malhotra, Sushant,Koschker, Philipp,Ellerbrock, Pascal
supporting information; experimental part, p. 2075 - 2084 (2012/03/12)
A novel synthetic strategy toward the asymmetric synthesis of vicinal diols bearing a tertiary center is presented. The method encompasses the dinuclear Mg-catalyzed asymmetric addition of ethyl diazoacetate into several aldehydes, oxidation of the diazo functionality, and diastereoselective alkyl transfer of various organometallics into the resulting chiral β-hydroxy-α- ketoesters to afford a diverse range of 1,2-diols in high yield, diastereoselectivity, and chirality transfer.
