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1354792-75-8

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1354792-75-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1354792-75-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,4,7,9 and 2 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1354792-75:
(9*1)+(8*3)+(7*5)+(6*4)+(5*7)+(4*9)+(3*2)+(2*7)+(1*5)=188
188 % 10 = 8
So 1354792-75-8 is a valid CAS Registry Number.

1354792-75-8Relevant articles and documents

Copper-Catalyzed Deaminative Difluoromethylation

Cai, Aijie,Liu, Wei,Wang, Yufei,Yan, Wenhao,Yang, Dongqi,Yang, Kundi,Zacate, Samson B.,Zeng, Xiaojun

supporting information, p. 16398 - 16403 (2020/07/17)

The difluoromethyl group (CF2H) is considered to be a lipophilic and metabolically stable bioisostere of an amino (NH2) group. Therefore, methods that can rapidly convert an NH2 group into a CF2H group would be of great value to medicinal chemistry. We report herein an efficient Cu-catalyzed approach for the conversion of alkyl pyridinium salts, which can be readily synthesized from the corresponding alkyl amines, to their alkyl difluoromethane analogues. This method tolerates a broad range of functional groups and can be applied to the late-stage modification of complex amino-containing pharmaceuticals.

Copper-Catalyzed Decarboxylative Difluoromethylation

Zeng, Xiaojun,Yan, Wenhao,Zacate, Samson B.,Chao, Tzu-Hsuan,Sun, Xiaodong,Cao, Zhi,Bradford, Kate G. E.,Paeth, Matthew,Tyndall, Sam B.,Yang, Kundi,Kuo, Tung-Chun,Cheng, Mu-Jeng,Liu, Wei

supporting information, p. 11398 - 11403 (2019/08/20)

We report herein a highly efficient Cu-catalyzed protocol for the conversion of aliphatic carboxylic acids to the corresponding difluoromethylated analogues. This robust, operationally simple and scalable protocol tolerates a variety of functional groups and can convert a diverse array of acid-containing complex molecules to the alkyl-CF2H products. Mechanistic studies support the involvement of alkyl radicals.

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