1354801-06-1

Basic information

• Product Name: 5H-Pyrrolo[2,3-b:5,4-c']dipyridine, 6,7,8,9-tetrahydro-, hydrochloride
• Synonyms: 5H-Pyrrolo[2,3-b:5,4-c']dipyridine, 6,7,8,9-tetrahydro-, hydrochloride;6,7,8,9-Tetrahydro-5H-pyrrolo[2,3-b:5,4-c]dipyridine hydrochloride
• CAS NO: 1354801-06-1
• Molecular Formula: C₁₀H₁₁N₃*ClH
• Molecular Weight: 209.67538
• Mol File: 1354801-06-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 5H-Pyrrolo[2,3-b:5,4-c']dipyridine, 6,7,8,9-tetrahydro-, hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-Pyrrolo[2,3-b:5,4-c']dipyridine, 6,7,8,9-tetrahydro-, hydrochloride(1354801-06-1)
• EPA Substance Registry System: 5H-Pyrrolo[2,3-b:5,4-c']dipyridine, 6,7,8,9-tetrahydro-, hydrochloride(1354801-06-1)

Safety Data

• Hazardous Substances Data: 1354801-06-1(Hazardous Substances Data)

Usage

General Description

5H-Pyrrolo[2,3-b:5,4-c']dipyridine, 6,7,8,9-tetrahydro-, hydrochloride is a chemical compound that is often used in the field of pharmaceuticals and research. It is a heterocyclic compound with a pyrrolopyridine core and is typically found in the form of a hydrochloride salt. 5H-Pyrrolo[2,3-b:5,4-c']dipyridine, 6,7,8,9-tetrahydro-, hydrochloride has potential applications in the development of new drugs and therapeutics, as well as in scientific research for its unique structural and functional properties. Its hydrochloride form makes it more stable and easier to handle in laboratory settings, and it may be used in the synthesis of pharmaceutical compounds or as a research tool for studying biological processes.

Upstream product

• 271-63-6 7-Azaindole 
• 50-00-0 formaldehyd 
• 4649-12-1 2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-ethylamine 
• 5654-92-2 7-azagramine 
• 183208-29-9 3-(2-nitroethyl)-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

ONO-8430506: A Novel Autotaxin Inhibitor That Enhances the Antitumor Effect of Paclitaxel in a Breast Cancer Model

Lysophosphatidic acid (LPA) is a bioactive lipid mediator that elicits a number of biological functions, including smooth muscle contraction, cell motility, proliferation, and morphological change. LPA is endogenously produced by autotaxin (ATX) from extracellular lysophosphatidylcholine (LPC) in plasma. Herein, we report our medicinal chemistry effort to identify a novel and highly potent ATX inhibitor, ONO-8430506 (20), with good oral availability. To enhance the enzymatic ATX inhibitory activity, we designed several compounds by structurally comparing our hit compound with the endogenous ligand LPC. Further optimization to improve the pharmacokinetic profile and enhance the ATX inhibitory activity in human plasma resulted in the identification of ONO-8430506 (20), which enhanced the antitumor effect of paclitaxel in a breast cancer model.