1354819-22-9

Upstream product

• 1354819-21-8 N-(2,4-dimethoxybenzyl)-5-fluoropyrimidin-2-amine 
• 13656-57-0 5-chloro-2,4-difluorobenzene-1-sulfonyl chloride 
• 20781-20-8 2,4-Dimethoxybenzylamine 

Downstream Products

• 1354819-24-1 4-[2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 
• 1354818-84-0 4-[2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 4-methylbenzenesulfonate 

Relevant academic research and scientific papers

The discovery of tetrahydropyridine analogs as hNav1.7 selective inhibitors for analgesia

hNav1.7 small molecular inhibitors have attracted lots of attention by its unique analgesic effect. Herein, we report the design and synthesis of a novel series of tetrahydropyridine analogs as hNav1.7 inhibitors for analgesia. Detail structural–activity

CHEMICAL COMPOUNDS

The invention relates to new sulfonamide Nav1.7 inhibitors and pharmaceutically acceptable salts thereof, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. Nav 1.7 in