135484-48-9

Basic information

• Product Name: ({[1-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-fluoropropan-2-yl]oxy}methyl)phosphonic acid
• CAS NO: 135484-48-9
• Molecular Formula: C₉H₁₃FN₅O₅P
• Molecular Weight: 321.2022
• Mol File: 135484-48-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 734.5°C at 760 mmHg
• Flash Point: 398°C
• Density: 1.99g/cm³
• Vapor Pressure: 1.19E-22mmHg at 25°C
• Refractive Index: 1.746
• CAS DataBase Reference: ({[1-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-fluoropropan-2-yl]oxy}methyl)phosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: ({[1-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-fluoropropan-2-yl]oxy}methyl)phosphonic acid(135484-48-9)
• EPA Substance Registry System: ({[1-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-fluoropropan-2-yl]oxy}methyl)phosphonic acid(135484-48-9)

Safety Data

• Hazardous Substances Data: 135484-48-9(Hazardous Substances Data)

Usage

General Description

The chemical compound "({[1-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-fluoropropan-2-yl]oxy}methyl)phosphonic acid" is a phosphonic acid derivative with a complex molecular structure. It contains a purine base, a fluoropropane group, and a phosphonic acid moiety. The compound is a nucleotide analogue and has potential applications in antiviral and antitumor therapies. The specific arrangement of atoms and functional groups in the molecule gives it unique properties and biological activities, making it a subject of interest for further research and development in the field of medicinal chemistry.

Upstream product

• 138870-24-3 N⁶-benzoyl-9-(RS)-(3-fluoro-2-hydroxypropyl)guanine 
• 138870-30-1 9-(3-fluoro-2-hydroxypropyl)guanine 

Relevant articles and documents

SYNTHESIS OF N-(3-FLUORO-2-PHOSPHONOMETHOXYPROPYL) (FPMP) DERIVATIVES OF HETEROCYCLIC BASES

A new groupnof compounds has been prepared: N-(3-fluoro-2-phosphonomethoxypropyl) (FPMP) derivatives of purine and pyrimidine bases which exhibit a significant selective activity against a broad spectrum of retroviruses.Racemic N-(3-fluoro-2-phosphonomethoxypropyl) derivatives of adenine (V), guanine (IX), cytosine (XIII), 2,6-diaminopurine (XXI), 3-deazaadenine (XVII), xanthine (X) and hypoxanthine (VI) were prepared from the corresponding n-(3-fluoro-2-hydroxypropyl) derivatives after protection of amino group at the heterocyclic ring by selective benzoylation, reaction with diisopropyl p-toluenesulfonyloxymethylphosphonate (II), and subsequent removal of the protecting groups.Chiral FPMP derivatives were prepared by reaction of heterocyclic base with corresponding chiral synthon (XXX; XXXVII) followed by deprotection.The required chiral synthons were obtained from enantiomeric 3-fluoro-1,2-propanediols by two methods.In the first, the primary hydroxyl group was tritylated, the obtained derivative was reacted with compound II, the trityl group was removed and the product was mesylated to give synthon XXXVII.The second pathway considered tosylation of the primary hydroxyl group and conversion of the secondary hydroxyl into the acetoxymethyl ether via the methoxymethyl ether; treatment of the acetoxy compound with bromotrimethylsilane and triisopropyl phosphite afforded the desired synthon XXX.