135491-08-6Relevant articles and documents
Preparation and Properties of ω-Phosphino-phosphoniocarboxylic Acids and their Betaines
Aly, Aref A. M.,Schmidbaur, Hubert
, p. 775 - 778 (2007/10/02)
In an attempt to provide phosphorus analogues of aminocarboxylic acids and their betaines, α,ω-bis(diphenylphosphino)alkanes (dppm, dppe, dppp, dppb) were converted into ω-phosphino-phosphoniocarboxylates and diphosphonio-biscarboxylates.While the reactions with haloacetic acids or haloacetates only lead to methylphosphonium derivatives owing to decarboxylation of the intermediates, β-chloropropionic acids converts Ph2P(CH2)nPPh2 compounds into the target products Ph2PCH2PPh2+(CH2)2COOHCl- (1) and CH22*2Cl- (2), for n = 1.For n = 2, 3 and 4, only the analogues of 2 could be prepared (3-5).Treatment of 1 and 2 with sodium bicarbonate afforded the corresponding betaines Ph2PCH2PPh2+CH2CH2COO- (isolated as a dihydrate 6) and CH2+CH2CH2COO->2 (isolated as the tetrahydrate 7).