1354912-43-8

Basic information

• Product Name: C₁₉H₁₃N₃O₄S
• CAS NO: 1354912-43-8
• Molecular Weight: 379.396
• Mol File: 1354912-43-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₃N₃O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₃N₃O₄S(1354912-43-8)
• EPA Substance Registry System: C₁₉H₁₃N₃O₄S(1354912-43-8)

Safety Data

• Hazardous Substances Data: 1354912-43-8(Hazardous Substances Data)

Upstream product

• 1009826-84-9 methyl 5-chlorobenzo[c][2,6]naphthyridine-8-carboxylate 
• 850568-74-0 3-(dihydroxyboranyl)benzene-1-sulfonamide 

Relevant articles and documents

Synthesis and SAR of inhibitors of protein kinase CK2: Novel tricyclic quinoline analogs

Protein kinase CK2 is a potential drug target for many diseases including cancer and inflammation disorders. The crystal structure of clinical candidate CX-4945 1 with CK2 revealed an indirect interaction with the protein through hydrogen bonding between the NH of the 3-chlorophenyl amine and a water molecule. Herein, we investigate the relevance of this hydrogen bond by preparing several novel tricyclic derivatives lacking a NH moiety at the same position. This SAR study allowed the discovery of highly potent CK2 inhibitors.