1354948-47-2

Upstream product

• 216854-23-8 tert-butyl (S)-piperidin-3-yl-carbamate 
• 99769-19-4 [3-(methoxycarbonyl)phenyl]boronic acid 
• 1354948-39-2 C₁₃H₁₈N₂O₂ 
• 15911-30-5 4-methyl-2-(4-nitrophenyl)-1,3-thiazole-5-carboxylic acid 
• 1232775-10-8 methyl 3-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}benzoate 

Relevant academic research and scientific papers

Discovery of cyclic amine-substituted benzoic acids as PPARα agonists

A series of novel cyclic amine-substituted benzoic acid derivatives were synthesized and evaluated for their PPARα agonist activity. Strucure-activity relationship studies led to the identification of (S)-3-[3-[2-(4-chlorophenyl)-4-methylthyazole-5-carboxamido]piperidin-1-yl] benzoic acid (S)-4f (KRP-105) as a potent and high subtype-selective human PPARα agonist. (S)-4f showed excellent PK profile and oral administration of (S)-4f to high-fat diet dogs effectively lowered triglycerides.