Welcome to LookChem.com Sign In|Join Free
  • or
4',5'-Didehydro-4'-deoxy-2',19'-dioxo-2',19'-secovincaleukoblastine is a complex chemical compound derived from the Vinca alkaloids, a group of indole alkaloids found in the Madagascar periwinkle plant (Catharanthus roseus). This specific compound is a semi-synthetic derivative of the parent Vinca alkaloid, vincaleukoblastine, and is characterized by the presence of a double bond between the 4' and 5' carbon atoms, the absence of a hydroxyl group at the 4' position, and the presence of two oxygen atoms at the 2' and 19' positions. The compound exhibits potent anti-cancer properties, primarily through its ability to inhibit microtubule assembly and disrupt the mitotic spindle during cell division. Due to its complex structure and potential therapeutic applications, 4',5'-Didehydro-4'-deoxy-2',19'-dioxo-2',19'-secovincaleukoblastine has been the subject of extensive research in the field of cancer chemotherapy.

1355-31-3

Post Buying Request

1355-31-3 Suppliers

Recommended suppliers

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1355-31-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1355-31-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,3,5 and 5 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1355-31:
(6*1)+(5*3)+(4*5)+(3*5)+(2*3)+(1*1)=63
63 % 10 = 3
So 1355-31-3 is a valid CAS Registry Number.
InChI:InChI=1/C46H54N4O10/c1-8-28-21-29(53)24-45(41(54)58-6,37-31(15-19-49(25-28)26-51)30-13-10-11-14-34(30)47-37)33-22-32-35(23-36(33)57-5)48(4)39-44(32)17-20-50-18-12-16-43(9-2,38(44)50)40(60-27(3)52)46(39,56)42(55)59-7/h10-14,16,22-23,25-26,38-40,47,56H,8-9,15,17-21,24H2,1-7H3/b28-25-

1355-31-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Alkaloid XC-99

1.2 Other means of identification

Product number -
Other names 4',5'-Didehydro-4'-deoxy-2',19'-dioxo-2',19'-secovincaleukoblastine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1355-31-3 SDS

1355-31-3Downstream Products

1355-31-3Relevant academic research and scientific papers

ALKALOID PRODUCTION IN CATHARANTHUS ROSEUS (L.) G. DON CELL CULTURES. XIV. THE ROLE OF UNSTABLE DIHYDROPYRIDINIUM INTERMEDIATES IN THE BIOSYNTHESIS OF BISINDOLE ALKALOIDS

Kutney, James Peter,Boulet, Camille Andre,Choi, Lewis Siu Leung,Gustowski, Wlodzimierz,McHugh, Michael,et al.

, p. 613 - 620 (2007/10/02)

Employing enzyme systems obtained from Catharanthus roseus cell cultures, experiments relating to the biosynthesis of various bisindole alkaloids are described.Specifically, the enzyme-catalyzed coupling of catharanthine (1) and vindoline (2) to a highly unstable dihydropyridinium intermediate (9), important in the biosynthesis of 3',4'-anhydrovinblastine (3), leurosine (4), catharine (6), vinamidine (7) and hydroxyvinamidine (8) is presented.Conversions of 9 to these alkaloids and its role in the biosynthesis is discussed.Although catharanthine is well utilized by the enzyme system, catharanthine N-oxide (10), an important intermediate in the chemical coupling of 1 and 2 to afford 9, is not utilized.

ALKALOID PRODUCTION IN CATHARANTHUS ROSEUS (L.) G. DON CELL CULTURES. XVI. BIOTRANSFORMATION OF 3',4'-ANHYDROVINBLASTINE WITH CATHARANTHUS ROSEUS CELL CULTURES AND ENZYME SYSTEMS

Kutney, James Peter,Botta, Bruno,Boulet, Camille Andre,Buschi, Carlos Alberto,Choi, Lewis Siu Leung,et al.

, p. 629 - 638 (2007/10/02)

Employing cell cultures of Catharanthus roseus and enzyme systems derived from such cultures, a detailed study of the biotransformation of 3',4'-anhydrovinblastine (3) is described.It is shown that enzymatic conversion of 3 to the isolated end products, the bisindole alkaloids leurosine (4), vinblastine (5), catharine (6), vinamidine (7) and hydroxyvinamidine (8) proceeds initially to the same dihydropyridinium intermediate (9) obtained when the monomeric alkaloids catharanthine (1) and vindoline (2) are enzymatically coupled.These data establish that the overall biosynthetic pathway to the bisindole alkaloids proceeds from 1 and 2 to the initially formed 9 and the latter, under enzymatically controlled oxidation-reduction, affords the alkaloids 3-8.However, when 3 is incubated as substrate, the enzymes are capable of utilizing and converting it into the alkaloids 4-8.In summary, 3 is not a direct biosynthetic precursor of 4-8.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 1355-31-3