1355018-65-3

Upstream product

• 1354577-67-5 tert-butyl (S)-3-allyl-1-benzhydryl-2-oxopiperidine-3-carboxylate 
• 1354577-53-9 N⁽¹⁾-benzhydryl-2-piperidone 
• 1355018-63-1 methyl (R)-1-benzhydryl-3-(5-ethoxy-5-oxopentyl)-2-oxopiperidine-3-carboxylate 
• 1355018-64-2 ethyl (6S)-2-benzhydryl-1,7-dioxo-2-azaspiro[5.5]undecane-8-carboxylate 
• 1355018-60-8 (S)-2-benzhydryl-2-azaspiro[5.5]undecane-1,7-dione 
• 1355018-59-5 tert-butyl (R)-1-benzhydryl-3-(5-ethoxy-5-oxopentyl)-2-oxopiperidine-3-carboxylate 
• 1355018-62-0 tert-butyl (3S)-1-benzhydryl-3-{5-ethoxy-2-[(ethoxycarbonothioyl)thio]-5-oxopentyl}-2-oxopiperidine-3-carboxylate 
• 1355018-61-9 tert-butyl (S)-1-benzhydryl-3-(2-bromoallyl)-2-oxopiperidine-3-carboxylate 

Downstream Products

• 1355018-66-4 (6R,7R)-2-benzhydryl-2-azaspiro[5.5]undecan-7-ol 
• 49620-06-6 (+)-isonitramine 

Relevant academic research and scientific papers

Enantioselective Total Synthesis of Nitraria Alkaloids: (+)-Nitramine, (+)-Isonitramine, (-)-Isonitramine, and (-)-Sibirine via Asymmetric Phase-Transfer Catalytic α-Allylations of α-Carboxylactams

Many optically active 2-azaspirocyclic structures have frequently been found in biologically active natural products. In particular, Nitraria alkaloids, (+)-nitramine, (+)-isonitramine, (-)-isonitramine, and (-)-sibirine, have stereogenicity on their quat

Highly enantioselective total synthesis of (+)-isonitramine

A new efficient enantioselective synthetic method of (+)-isonitramine is reported. (+)-Isonitramine was obtained in 12 steps (98% ee and 43% overall yield) from δ-valerolactam via enantioselective phase-transfer catalytic alkylation, Dieckman condensation