1355024-32-6

Basic information

• Product Name: tert-butyl 2-phenyl-2-(pyrrolidin-1-yl)acetate
• Synonyms: tert-butyl 2-phenyl-2-(pyrrolidin-1-yl)acetate
• CAS NO: 1355024-32-6
• Molecular Weight: 261.364
• Mol File: 1355024-32-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-phenyl-2-(pyrrolidin-1-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-phenyl-2-(pyrrolidin-1-yl)acetate(1355024-32-6)
• EPA Substance Registry System: tert-butyl 2-phenyl-2-(pyrrolidin-1-yl)acetate(1355024-32-6)

Safety Data

• Hazardous Substances Data: 1355024-32-6(Hazardous Substances Data)

Upstream product

• 86517-04-6 4-chlorobutylmagnesium bromide 
• 7332-98-1 tert-butyl phenylglyoxylate 
• 108-86-1 bromobenzene 

Downstream Products

• 1338795-37-1 1-(carboxy(phenyl)methyl)pyrrolidinium 2,2,2-trifluoroacetate 

Relevant articles and documents

Tandem N, N-Dialkylation Reaction of N-Trimethylsilyl α-Iminoesters Utilizing an Umpolung Reaction and Characteristics of the Silyl Substituent: Synthesis of Pyrrolidine, Piperidine, and Iminodiacetate

Umpolung reactions of N-trimethylsilyl α-iminoester with organometallics gave directly N-alkylaminoesters in high yields without the need for removing a protecting group at the nitrogen atom. Efficient syntheses of pyrrolidines, piperidines, and iminodiacetate derivatives were also developed via tandem N,N- or N,C-dialkylation reactions utilizing characteristics of the silyl substituent. Furthermore, under the influence of silica gel, the addition of an enolate to the imino nitrogen proceeded to give an iminodiacetate derivative.

KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME

The present teachings provide a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Also described are a pharmaceutical composition and method of use thereof.