135503-02-5

Upstream product

• 59485-81-3 cis-1-chloro-9-octadecene 
• 931-15-7 (1S,2S)-trans-2-aminocyclohexanol 

Relevant academic research and scientific papers

Pantothenic acid derivatives

Compounds represented by general formula (I) below STR1 wherein R1 and R2, which are the same or different, each represent a hydrogen atom or a protective group for a hydroxyl group; R3 represents a saturated or unsaturated, linear, branched or cyclic, monovalent C5 ?C25 -aliphatic hydrocarbon group which may be substituted with an aromatic group, or a group of formula STR2 where R4 represents a saturated or unsaturated, linear, branched or cyclic, monovalent C5 ?C25 -aliphatic hydrocarbon group which may be substituted with an aromatic group, and R5 represents a hydrogen atom, or a saturated or unsaturated, linear, branched or cyclic, monovalent hydrovarbon group which may be substituted with an aromatic group; Q represents (a) a group of formula --X1 --A--Y1 --, where A represents a saturated or unsaturated, linear, branched or cyclic divalent C2 ?C16 -aliphatic hydrocarbon group which may be substituted with an aromativ group, a divalent aromatic hydrocarbon group or a divalent aromatic heterocyclic group; one of X1 and Y1 represents STR3 and the other represents --O--, --S-- or STR4 in which R6 and R7 each represent a hydrogen atom or a lower alkyl group; (b) a group of formula --X2 --(CH2)l --Y2 --, where one of X2 and Y2 represents a group of formula STR5 and the other represents --O--, --S-- or STR6 in which STR7 represents a 4?7-membered, divalent nitrogen-containing aromatic heterocyclic group, and R6 has the same meaning as defined above, and l is 0, 1 or 2; or (c) a group of formula STR8 where m is 2 or 3; n is an integer of from 1 to 4. The compounds have excellent inhibitory activity against acyl Co A-cholesterol-acyltransferase.

Pantothenic acid derivatives

Compounds represented by general formula (I) below wherein R1 and R2, which are the same or different, each represent a hydrogen atom or a protective group for a hydroxyl group;, R3 represents a saturated or unsaturated, linear, branched or cyclic, monovalent C5～C25-aliphatic hydrocarbon group which may be substituted with an aro-matic group, or a group of formula where R4 represents a saturated or unsaturated, linear, branched or cyclic, monovalent C5～C25--aliphatic hydrocarbon group which may be sub-stituted with an aromatic group, and, R5 represents a hydrogen atom, or a saturated or unsaturated, linear, branched or cyclic, monovalent hydrocarbon group which may be substituted with an aromatic group; Q represents (a) a group of formula -X1-A-Y1-,where A represents a saturated or unsaturated, linear, branched or cyclic divalent C2～C16--aliphatic hydrocarbon group which may be sub-stituted with an aromatic group, a divalent aromatic hydrocarbon group or a divalent aro-matic heterocyclic group;, one of X1 and Y1 represents and the other represents -O-, -S- or in which R6 and R7 each represent a hydrogen atom or a lower alkyl group; (b) a group of formula -X2-(CH2)l-Y2-,where one of X2 and Y2 represents a group of formula and the other represents -O-, -S- or represents a 4～7--membered, divalent nitrogen-containing aromatic heterocyclic group, and R6 has the same meaning as defined above, and l is 0, 1 or 2; or (c) a group of formula where m is 2 or 3;, n is an integer of from 1 to 4. The compounds have excellent inhibitory activ-ity against acyl Co A-cholesterol-acyltransferase.