135504-89-1

Basic information

• Product Name: (1'R)-3-Hydroxy-3-(1,4,5,8-tetramethoxynaphthyl)propanoic Acid 2'-Hydroxy-1',2',2'-triphenylethyl Ester
• CAS NO: 135504-89-1
• Molecular Weight: 608.688
• Mol File: 135504-89-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1'R)-3-Hydroxy-3-(1,4,5,8-tetramethoxynaphthyl)propanoic Acid 2'-Hydroxy-1',2',2'-triphenylethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1'R)-3-Hydroxy-3-(1,4,5,8-tetramethoxynaphthyl)propanoic Acid 2'-Hydroxy-1',2',2'-triphenylethyl Ester(135504-89-1)
• EPA Substance Registry System: (1'R)-3-Hydroxy-3-(1,4,5,8-tetramethoxynaphthyl)propanoic Acid 2'-Hydroxy-1',2',2'-triphenylethyl Ester(135504-89-1)

Safety Data

• Hazardous Substances Data: 135504-89-1(Hazardous Substances Data)

Upstream product

• 95061-47-5 (R)-2-acetoxy-1,1,2-triphenylethanol 
• 88818-28-4 1,4,5,8-tetramethoxynaphthalene-2-carbaldehyde 

Downstream Products

• 517-89-5 shikonin 

Relevant articles and documents

Synthesis of Shikonin and Alkannin

The enantiomeric naturally occurring naphthoquinones shikonin and alkannin have been synthesized in a thirteen-step procedure in 44 to 65percent e.e.The stereogenic centers of (R)-1 and (S)-1 are created by the reaction of naphthaldehyde 3 with (R)- and (S)-2-hydroxy-1,2,2-triphenylethyl acetate (2), respectively.In order to find out a rationalization for the unexpectedly low diastereoselectivity in this aldol addition, a series of substituted aromatic aldehydes 12a-h has been treated with (R)-2. Key words: Naphthoquinone / Aldol addition / (R)-Shikonin / (S)-Alkannin