1355049-97-6

Basic information

• Product Name: (3R,4R,5R)-4-(benzyloxy)-5-(benzyloxymethyl)-3-fluoro-dihydrofuran-2(3H)-one
• Synonyms: (3R,4R,5R)-4-(benzyloxy)-5-(benzyloxymethyl)-3-fluoro-dihydrofuran-2(3H)-one;2-Deoxy-2-fluoro-3,5-bis-O-(phenylmethyl)-D-ribonic acid gamma-lactone;(3R,4R,5R)-4-Benzyloxy-5-(benzyloxymethyl)-3-fluoro-tetrahydrofuran-2-one
• CAS NO: 1355049-97-6
• Molecular Formula: C₁₉H₁₉FO₄
• Molecular Weight: 330.3501632
• Mol File: 1355049-97-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 472.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• CAS DataBase Reference: (3R,4R,5R)-4-(benzyloxy)-5-(benzyloxymethyl)-3-fluoro-dihydrofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4R,5R)-4-(benzyloxy)-5-(benzyloxymethyl)-3-fluoro-dihydrofuran-2(3H)-one(1355049-97-6)
• EPA Substance Registry System: (3R,4R,5R)-4-(benzyloxy)-5-(benzyloxymethyl)-3-fluoro-dihydrofuran-2(3H)-one(1355049-97-6)

Safety Data

• Hazardous Substances Data: 1355049-97-6(Hazardous Substances Data)

Usage

Uses

(3R,?4R,?5R)?-?4-?(Benzyloxy)?-?5-?((benzyloxy)?methyl)?-?3-?fluorodihydrofuran-?2(3H)?-?one is a reagent used in the preparation of Favipiravir analogues used in the treatment of influenza.

Upstream product

• 863642-44-8 methyl 3,5-di-O-benzyl-2-deoxy-2-fluoro-α/β-D-ribofuranoside 

Downstream Products

• 1355049-98-7 (3R,4R,5R)-2-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-4-(benzyloxy)-5-(benzyloxymethyl)-3-fluorotetrahydrofuran-2-ol 
• 1355050-03-1 C₂₆H₂₇FN₄O₃ 
• 1365477-42-4 (3R,4R,5R)-2-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-4-(benzyloxy)-5-(benzyloxymethyl)-3-fluorotetrahydrofuran-2-ol 
• 1456712-46-1 (2S,3R,4R,5R)-4-(benzyloxy)-5-(benzyloxymethyl)-2-(4-ethoxy-2-(methylthio)imidazo[2,1-f][1,2,4]-triazin-7-yl)-3-fluorotetrahydrofuran-2-ol 
• 1456712-33-6 (2S,3R,4R,5R)-4-(benzyloxy)-5-(benzyloxymethyl)-2-(2,4-bis(methylthio)imidazo[2,1-f][1,2,4]triazin-7-yl)-3-fluorotetrahydrofuran-2-ol 
• 1456712-43-8 7-((2S,3R,4R,5R)-4-(benzyloxy)-5-(benzyloxymethyl)-3-fluorotetrahydrofuran-2-yl)-2-fluoroimidazo[2,1-f][1,2,4]-triazin-4-amine 
• 1456712-41-6 (2S,3R,4R,5R)-7-(4-(benzyloxy)-5-(benzyloxymethyl)-3-fluorotetrahydrofuran-2-yl)imidazo[2,1-f][1,2,4]-triazine-4-amine 
• 1456712-38-1 (2S,3R,4R,5R)-5-(2,4-diaminoimidazo[2,1-f][1,2,4]-triazin-7-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol 
• 1456712-37-0 (2S,3R,4R,5R)-7-(4-(benzyloxy)-5-(benzyloxymethyl)-3-fluorotetrahydrofuran-2-yl)imidazo[2,1-f][1,2,4]-triazine-2,4-diamine 
• 1456712-36-9 (2S,3R,4R,5R)-7-(-4-(benzyloxy)-5-(benzyloxymethyl)-3-fluorotetrahydrofuran-2-yl)-2-(methylsulfonyl)imidazo[2,1-f][1,2,4]triazin-4-amine 

Relevant articles and documents

Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues

Influenza viruses are responsible for seasonal epidemics and occasional pandemics which cause significant morbidity and mortality. Despite available vaccines, only partial protection is achieved. Currently, there are two classes of widely approved anti-in

Compound containing guanidyl group, and preparation method and application thereof

The invention provides a preparation containing a guanidino compound and used for treating pneumoviridae virus infection, a method, a compound of a formula I, and a method and an intermediate for synthesizing the compound of the formula I.

METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS

Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.