1355091-47-2Relevant academic research and scientific papers
Spiro-1-benzofuranpiperidinylalkanoic acids as a novel and selective sphingosine S1P5 receptor agonist chemotype
Stoit, Axel R.,Lange, Jos H.M.,Coolen, Hein K.A.C.,Rensink, Annemieke,van den Hoogenband, Adri,den Hartog, Arnold P.,van Schaik, Sjoerd,Kruse, Chris G.
, p. 459 - 465 (2018/01/01)
The synthesis and SAR of a novel class of spirobenzofuranpiperidinyl-derived alkanoic acids 6–34 as sphingosine S1P5 receptor agonists are described. The target compounds generally elicit high S1P5 receptor agonistic potencies and in general are selective against both S1P1 and S1P3 receptor subtypes. The key compound 32 shows a high bioavailability of 73% and a CNS/plasma ratio of 0.8 after oral administration in rats.
SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS
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Page/Page column 209-210, (2012/02/01)
The present invention relates spiro- cyclic amine derivatives of the formula (I) wherein R1; R2; R3; Q; -W-T-; R5; Z; and A have the definitions provided in the claims; or a pharmaceutically acceptable salt, a solvate or hydrate thereof or one or more N-oxides thereof. The compounds of the invention have affinity to S1P receptors and may be used in the treatment, alleviation or prevention of diseases and conditions in which (a) SIP receptor (s) is (are) involved
