1355199-46-0

Basic information

• Product Name: [Rh((S,S)-QuinoxP*)(cod)]SbF₆
• CAS NO: 1355199-46-0
• Molecular Weight: 781.21
• Mol File: 1355199-46-0.mol

Chemical Properties

• CAS DataBase Reference: [Rh((S,S)-QuinoxP*)(cod)]SbF₆(CAS DataBase Reference)
• NIST Chemistry Reference: [Rh((S,S)-QuinoxP*)(cod)]SbF₆(1355199-46-0)
• EPA Substance Registry System: [Rh((S,S)-QuinoxP*)(cod)]SbF₆(1355199-46-0)

Safety Data

• Hazardous Substances Data: 1355199-46-0(Hazardous Substances Data)

Upstream product

• 1107608-80-9 (R,R)-(-)-2,3-bis(tert-butylmethylphosphino)qinoxaline 
• 1107608-80-9 (S,S)-2,3-bis(tert-butylmethylphosphino)quinoxaline 
• 1107608-80-9 2,3-bis[(S)-(1,1-dimethylethyl)methylphosphino]quinoxaline 

Relevant articles and documents

Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation

Here, we report the first synthesis of quasi-stable trimer models of full-length Aβ40 with a toxic conformation using a 1,3,5-phenyltris-l-alanyl linker at position 34, 36, or 38. The only trimer to exhibit weak neurotoxicity against SH-SY5Y cells was the one which was linked at position 38. This suggests that such a propeller-type trimer model is not prone to forming oligomers with potent neurotoxicity, which is in contrast with its corresponding dimer model.

Rigid P-chiral phosphine ligands with tert -butylmethylphosphino groups for rhodium-catalyzed asymmetric hydrogenation of functionalized alkenes

Both enantiomers of 2,3-bis(tert-butylmethylphosphino)quinoxaline (QuinoxP*), 1,2-bis(tert-butylmethylphosphino)benzene (BenzP*), and 1,2-bis(tert-butylmethylphosphino)-4,5-(methylenedioxy)benzene (DioxyBenzP*) were prepared in short steps from enantiopure (S)- and (R)-tert-butylmethylphosphine-boranes as the key intermediates. All of these ligands were crystalline solids and were not readily oxidized on exposure to air. Their rhodium complexes exhibited excellent enantioselectivities and high catalytic activities in the asymmetric hydrogenation of functionalized alkenes, such as dehydroamino acid derivatives and enamides. The practical utility of these catalysts was demonstrated by the efficient preparation of several chiral pharmaceutical ingredients having an amino acid or a secondary amine component. A rhodium complex of the structurally simple ligand BenzP* was used for the mechanistic study of asymmetric hydrogenation. Low-temperature NMR studies together with DFT calculations using methyl α-acetamidocinnamate as the standard model substrate revealed new aspects of the reaction pathways and the enantioselection mechanism.