1355199-46-0Relevant articles and documents
Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation
Irie, Yumi,Hanaki, Mizuho,Murakami, Kazuma,Imamoto, Tsuneo,Furuta, Takumi,Kawabata, Takeo,Kawase, Taiji,Hirose, Kenji,Monobe, Yoko,Akagi, Ken-ichi,Yanagita, Ryo C.,Irie, Kazuhiro
supporting information, p. 182 - 185 (2019/01/04)
Here, we report the first synthesis of quasi-stable trimer models of full-length Aβ40 with a toxic conformation using a 1,3,5-phenyltris-l-alanyl linker at position 34, 36, or 38. The only trimer to exhibit weak neurotoxicity against SH-SY5Y cells was the one which was linked at position 38. This suggests that such a propeller-type trimer model is not prone to forming oligomers with potent neurotoxicity, which is in contrast with its corresponding dimer model.