13553-75-8Relevant academic research and scientific papers
Synthesis of 2-Aminoindoles through Gold-Catalyzed C-H Annulations of Sulfilimines with N-Arylynamides
Tian, Xianhai,Song, Lina,Rudolph, Matthias,Rominger, Frank,Hashmi, A. Stephen K.
, p. 4327 - 4330 (2019)
A new gold-catalyzed C-H annulation of sulfilimines with N-phenylynamides is presented. As key intermediates of this operationally simple reaction, the in situ generated α-imino gold carbenes insert into the ortho C-H bonds of the phenyl groups to afford 2-aminoindoles bearing a variety of substitution patterns in high selectivities. This reaction offers a facile approach to biologically important 2-aminoindoles by using inexpensive and readily available starting materials.
