135531-25-8

Basic information

• Product Name: BROMOCHLORONITROMETHANE
• Synonyms: BROMOCHLORONITROMETHANE;Bromochloronitromethane (>85%)
• CAS NO: 135531-25-8
• Molecular Formula: CHBrClNO2
• Molecular Weight: 174.38
• Product Categories: Aliphatics;Mutagenesis Research Chemicals;Aliphatics, Mutagenesis Research Chemicals
• Mol File: 135531-25-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 132.7°C at 760 mmHg
• Flash Point: 34°C
• Appearance: /
• Density: 2.106g/cm³
• Vapor Pressure: 8.77mmHg at 25°C
• Refractive Index: 1.522
• PKA: -0.76±0.50(Predicted)
• CAS DataBase Reference: BROMOCHLORONITROMETHANE(CAS DataBase Reference)
• NIST Chemistry Reference: BROMOCHLORONITROMETHANE(135531-25-8)
• EPA Substance Registry System: BROMOCHLORONITROMETHANE(135531-25-8)

Safety Data

• Hazardous Substances Data: 135531-25-8(Hazardous Substances Data)

Usage

Description

BROMOCHLORONITROMETHANE, a member of the Halonitromethanes (HNMs) class, is a chemical compound that has been identified as a disinfection byproduct (DBP) in drinking water. It is known for its mutagenic properties in Salmonella and its ability to induce DNA strand breaks in mammalian cells.

Uses

Used in Drinking Water Disinfection:
BROMOCHLORONITROMETHANE is used as a disinfection byproduct in the process of treating drinking water. Its presence indicates the effectiveness of the disinfection process, but it also raises concerns due to its mutagenic and DNA-damaging properties.
Used in Environmental and Health Research:
BROMOCHLORONITROMETHANE is used as a subject of study in environmental and health research to better understand the effects of disinfection byproducts on human health and the environment. This knowledge can help in developing safer and more effective water treatment methods.
Used in Analytical Chemistry:
BROMOCHLORONITROMETHANE can be used as a reference compound in analytical chemistry for the development and validation of methods to detect and quantify disinfection byproducts in water samples. This helps in assessing the quality of drinking water and ensuring public health safety.

InChI:InChI=1/CHBrClNO2/c2-1(3)4(5)6/h1H

Upstream product

• 134538-97-9 methyl bromochloronitroacetate 

Relevant articles and documents

Halonitromethane Drinking Water Disinfection Byproducts: Chemical Characterization and Mammalian Cell Cytotoxicity and Genotoxicity

Halonitromethanes are drinking water disinfection byproducts that have recently received a high priority for health effects research from the U.S. Environmental Protection Agency (EPA). Our purpose was to identify and synthesize where necessary the mixed halonitromethanes and to determine the chronic cytotoxicity and the acute genotoxicity of these agents in mammalian cells. The halonitromethanes included bromonitromethane (BNM), dibromonitromethane (DBNM), tribromonitromethane (TBNM), bromochloronitromethane (BCNM), dibromochloronitromethane (DBCNM), bromodichloronitromethane (BDCNM), chloronitromethane (CNM), dichloronitromethane (DCNM), and trichloronitromethane (TCNM). Low- and high-resolution gas chromatography/mass spectrometry (GC/MS) was used to identify the mixed chloro-bromonitromethanes in finished drinking waters, and analytical standards that were not commercially available were synthesized (BDCNM, DBCNM, TBNM, CNM, DCNM, BCNM). The rank order of their chronic cytotoxicity (72 h exposure) to Chinese hamster ovary (CHO) cells was DBNM > DBCNM > BNM > TBNM > BDCNM > BCNM > DCNM > CNM > TCNM. The rank order to induce genomic DNA damage in CHO cells was DBNM > BDCNM > TBNM > TCNM > BNM > DBCNM > BCNM > DCNM > CNM. The brominated nitromethanes were more cytotoxic and genotoxic than their chlorinated analogues. This research demonstrated the integration of the procedures for the analytical chemistry and analytical biology when working with limited amounts of sample. The halonitromethanes are potent mammalian cell cytotoxins and genotoxins and may pose a hazard to the public health and the environment.