1355466-52-2

Upstream product

• 1355466-53-3 C₁₃H₁₅N₃O 

Downstream Products

• 1422541-95-4 1-(3,4-dihydro-3-m-tolyl-2-(1H-1,2,4-triazol-1-yl)quinazolin-4-yl)-3,3-dimethylbutan-2-one 
• 1422541-94-3 1-(3,4-dihydro-3-phenyl-2-(1H-1,2,4-triazol-1-yl)quinazolin-4-yl)-3,3-dimethylbutan-2-one 

Relevant academic research and scientific papers

Synthesis, fungicidal activity, and sterol 14α-demethylase binding interaction of 2-azolyl-3,4-dihydroquinazolines on Penicillium digitatum

A series of new 2-azolyl-3,4-dihydroquinazolines 6 was synthesized by direct cyclization of imidazole or 1,2,4-triazole with carbodiimides 4, which were obtained from aza-Wittig reaction of iminophosphorane 3 with isocyanate. The preliminary bioassay results demonstrated that most of the 2-imidazolyl-3,4-dihydroquinazolines 6a-6i exhibited good to significant fungicidal activity against Penicillium digitatum, whereas 2-triazolyl-3,4- dihydroquinazolines 6j-6t exhibited low fungicidal activity. Some of the 2-imidazolyl-3,4-dihydroquinazolines 6a-6i also exhibited strong binding interaction with the cytochrome P450-dependent sterol 14α-demethylase (CYP51). For example, compound 6e showed the best fungicidal activity against P. digitatum with IC50 = 4.14 μg/mL and the best CYP51 binding activity with Kd = 0.34 μg/mL, both superior to those of the agricultural fungicide triadimefon.