1355617-72-9Relevant academic research and scientific papers
A three-step protocol for lead optimization: Quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors
Huang, Xianhai,Zhu, Xiaohong,Chen, Xiao,Zhou, Wei,Xiao, Dong,Degrado, Sylvia,Aslanian, Robert,Fossetta, James,Lundell, Daniel,Tian, Fang,Trivedi, Prashant,Palani, Anandan
scheme or table, p. 65 - 70 (2012/02/16)
A three-step protocol for SAR development was introduced and applied to the SAR studies of the MK2 inhibitor program. Following this protocol, key conformational features and functional groups for improving MK2 inhibitor activity were quickly identified.
