135562-01-5Relevant academic research and scientific papers
Reactions of 3,6-bis(3,5-dimethyl-4-r-pyrazol-1-yl)-1,2,4,5-tetrazines with indole and 1,3,3-trimethyl-2-methyleneindoline
Ishmetova, Rashida I.,Ignatenko, Nina K.,Ganebnykh, Ilya N.,Tolshchina, Svetlana G.,Slepukhin, Pavel A.,Rusinov, Gennady L.
, p. 1363 - 1370 (2011)
It has been found that 3,6-bis(3,5-dimethyl-4-R-pyrazol-1-yl)-1,2,4,5- tetrazines react with indole and 1,3,3-trimethyl-2-methyleneindoline to give pyridazines as [4+2]cycloaddition products. 1,3,3-Trimethyl-2-methyleneindoline has been shown to act as C-nucleophile in the substitution of pyrazolyl group as well as in the reactions of tetrazine ring expansion in [1,2,4]triazolo[4,3-b] [1,2,4,5]tetrazine derivatives.
