135575-54-1

Basic information

• Product Name: 3-[5-({2-hydroxy-3-[(2-methylphenyl)amino]propyl}sulfanyl)-1,3,4-thiadiazol-2-yl]-2-methylquinazolin-4(3H)-one
• CAS NO: 135575-54-1
• Molecular Formula: C₂₁H₂₁N₅O₂S₂
• Molecular Weight: 439.5537
• Mol File: 135575-54-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 718.7°C at 760 mmHg
• Flash Point: 388.5°C
• Density: 1.42g/cm³
• Vapor Pressure: 1.12E-21mmHg at 25°C
• Refractive Index: 1.725
• CAS DataBase Reference: 3-[5-({2-hydroxy-3-[(2-methylphenyl)amino]propyl}sulfanyl)-1,3,4-thiadiazol-2-yl]-2-methylquinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[5-({2-hydroxy-3-[(2-methylphenyl)amino]propyl}sulfanyl)-1,3,4-thiadiazol-2-yl]-2-methylquinazolin-4(3H)-one(135575-54-1)
• EPA Substance Registry System: 3-[5-({2-hydroxy-3-[(2-methylphenyl)amino]propyl}sulfanyl)-1,3,4-thiadiazol-2-yl]-2-methylquinazolin-4(3H)-one(135575-54-1)

Safety Data

• Hazardous Substances Data: 135575-54-1(Hazardous Substances Data)

Upstream product

• 135575-72-3 3-(5-mercapto-1,3,4-thiadiazol-2-yl)-2-methyl-4(3H)-quinazolinone 
• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 135575-68-7 2-methyl-3-<5-<(oxiranylmethyl)thio>-1,3,4-thiadiazol-2-yl>-4(3H)-quinazolinone 
• 95-53-4 o-toluidine 

Relevant articles and documents

Substituted quinazolones as potent anticonvulsants and enzyme inhibitors

A series of 6,8-disubstituted 3-[5-[[-2-hydroxy-3-[(substituted phenyl)amino]propyl]thio]-1,3,4-thiadizol-2-yl]-2-methyl-4(3H)- quinazolinones were synthesized whose structures were confirmed by elemental analyses, IR, NMR and mass spectral studies. All these compounds were evaluated in vivo for anticonvulsant and analgesic activities and in vitro for monoamine oxidase and succinate dehydrogenase enzyme inhibitory activities using rat brain homogenate as a source of enzyme at final concentration of 1 x 10-4 mol/l. ALD50 values indicated their relatively nontoxic nature.