135578-99-3

Upstream product

• 38449-13-7 2-methyl-3-phenylacryloyl chloride 
• 71099-84-8 α-Methylzimtsaeureanilid 
• 62-53-3 aniline 
• 100-61-8 N-methylaniline 
• 1199-77-5 α-methylcinnamic acid 

Downstream Products

• 1587688-94-5 C₂₄H₂₁F₂NO₃S 
• 64754-83-2 (2S,3R)-2-Methyl-3-phenyl-oxirane-2-carboxylic acid methyl-phenyl-amide 

Relevant academic research and scientific papers

Photoredox Cyclization of N-Arylacrylamides for Synthesis of Dihydroquinolinones

Metal- and additive-free photoredox cyclization of N-arylacrylamides is herein reported that provides a concise access to the formation of dihydroquinolinones. In this protocol, sustainable visible light was used as the energy source, and the organic light-emitting molecule 4CzIPN served as the efficient photocatalyst. This reaction system features exclusive 6-endo-trig cyclization selectivity with a generally good yield of a range of functionalized dihydroquinolinones and dihydrobenzoquinolinones. Mechanistical studies reveal the feasibility of both 1,3-H shift and intersystem crossing of the diradical intermediate.

Metal-free synthesis of 3,3-disubstituted oxoindoles by iodine(III)-catalyzed bromocarbocyclizations

"I" did it: An iodine(III)-mediated bromocarbocyclization was elaborated as an efficient tool for the synthesis of oxoindoles. This method is applicable to a variety of structurally different substrates, also with chemically sensitive groups, and gives access to the heterocycles in a regio- and stereoselective fashion (see scheme). The indole-2-ones obtained can be converted easily into structurally complex target compounds, such as the alkaloid physostigmine. Copyright