1355952-68-9Relevant academic research and scientific papers
Total synthesis of sialic acid by a sequential rhodium-catalyzed aziridination and barbier allylation of D -glycal
Lorpitthaya, Rujee,Suryawanshi, Sharad B.,Wang, Siming,Pasunooti, Kalyan Kumar,Cai, Shuting,Ma, Jimei,Liu, Xue-Wei
, p. 12054 - 12057 (2012/02/14)
Acid test: Sialic acid Neu5Ac was synthesized in a regio and stereoselective manner from a glycal (see scheme) via a [1,2,3]-oxathiazocane-2, 2-dioxide intermediate. The sequential rhodium-catalyzed aziridination/indium- mediated Barbier allylation approach adopted offers a potentially flexible route to other sialic acid derivatives, since the oxathiazocane intermediate was compatible with a variety of nucleophiles. Copyright
