1355960-63-2Relevant academic research and scientific papers
Novel 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives as anti-tubercular agents
Telvekar, Vikas N.,Bairwa, Vinod Kumar,Satardekar, Kalpana,Bellubi, Anirudh
, p. 649 - 652 (2012)
A series of structurally novel, substituted 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives incorporating 2-hydrazinyl benzothiazole and 4-(aryloxy)benzaldehyde were designed and synthesized using molecular hybridization approach. All the synthesized compounds exhibited promising activity (MIC 1.5-29.00 μg/ml) against Mycobacterium tuberculosis H37Rv strains of using REMA. Five of the evaluated compounds exhibit MIC 3.0 μg/ml. Compound (E)-6-chloro-2-(2-(4-(2,4-dichlorophenoxy)benzylidene) hydrazinyl) benzothiazole showed MIC of 1.5 μg/ml. Thus, this compound could act as a potential lead for further development of new anti-tubercular drugs.
