1355969-25-3Relevant articles and documents
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity
Lee, Caroline A.,Jones III,Katayama, Jonathan,Kaspera, Ruediger,Jiang, Ying,Freiwald, Sascha,Smith, Evan,Walker, Gregory S.,Totah, Rheem A.
experimental part, p. 943 - 951 (2012/08/13)
CYP2J2, an arachidonic acid epoxygenase, is recognized for its role in the first-pass metabolism of astemizole and ebastine. To fully assess the role of CYP2J2 in drug metabolism, a selective substrate and potent specific chemical inhibitor are essential.