13560-93-5Relevant academic research and scientific papers
Unified Strategy for 1,5,9- and 1,5,7-Triols via Configuration-Encoded 1,5-Polyol Synthesis: Preparation and Coupling of C15-C25 and C26-C40 Fragments of Tetrafibricin
Friedrich, Ryan M.,Bell, Jay Q.,Garcia, Alfredo,Shen, Zican,Friestad, Gregory K.
, p. 13650 - 13669 (2018)
Diverse classes of natural products contain chiral 1,5,9- and 1,5,7-triol stereotriads, including the novel fibrinogen receptor antagonist tetrafibricin. Biological activities associated with compounds containing these motifs warrant targeted synthetic st
Intramolecular Michael reactions by iron(III) catalysis
Christoffers, Jens,Oertling, Heiko
, p. 1339 - 1344 (2000)
Seven-membered ring annulation is achieved by an intramolecular Michael reaction catalyzed by iron(III) chloride hexahydrate. Reaction conditions are mild and non-basic, and chemo- and stereoselectivity is excellent. Contrastingly, this method fails for a 17-membered ring annulation. (C) 2000 Elsevier Science Ltd.
