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• 65-22-5 pyridoxal hydrochloride 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 

Relevant academic research and scientific papers

Synthesis, structure and in vitro biological activity of pyridoxal N(4)-substituted thiosemicarbazone cobalt(III) complexes

Cobalt(III) complexes containing pyridoxal N(4)-substituted thiosemicarbazone ligands with the composition [Co(HL1-2·Cl) (HL1-2·H2O)] (1-2) have been synthesized from the reaction of [CoCl2(PPh3)

Ruthenium(II) carbonyl complexes containing pyridoxal thiosemicarbazone and trans-bis(triphenylphosphine/arsine): Synthesis, structure and their recyclable catalysis of nitriles to amides and synthesis of imidazolines

Pyridoxal N(4)-substituted thisemicarbazone hydrochloride ligands (L1-3) were synthesized and reacted with the ruthenium(II) starting complexes [RuHCl(CO)(EPh3)3] (EP or As). The resulting complexes [Ru(CO)(L1-3)(EPh3)2] (1-6) were characterized by elemental analyses and spectroscopic techniques. The molecular structure of complex 5 was identified by means of single crystal X-ray diffraction analysis. The catalytic activity of the new complexes was evaluated for the selective hydration of nitriles to primary amides and also the condensation of nitriles with ethylenediamine under solvent free conditions. The processes were operative with aromatic, heteroaromatic and aliphatic nitriles, and tolerated several substitutional groups. The studies on the effect of substitution over thiosemicarbazone, reaction time, temperature, solvent and catalyst loading were carried out in order to find the best catalyst in this series of complexes and favourable reaction conditions. A probable mechanism for both the catalytic reactions of nitrile has also been proposed. The catalyst was recovered and recycled in the hydration of nitriles for five times without any significant loss of its activity.

Synthesis, spectral characterization and crystal structure of Ni(II) pyridoxal thiosemicarbazone complexes and their recyclable catalytic application in the nitroaldol (Henry) reaction in ionic liquid media

The new square planar nickel(II) complexes 1, 2 and 3 have been synthesized from the reaction of [NiCl2(PPh3)2] with the tridentate Schiff base ligand, pyridoxal thiosemicarbazone (L1), pyridoxal N-methyl thiosemicarbazone (L2) and pyridoxal N-phenyl thiosemicarbazone (L3) respectively in ethanol. These complexes have been characterized by elemental analyses, IR, UV-Vis, 1H NMR, 31P NMR and ESI-MS spectroscopy. The molecular structure of the complex [Ni(L2)PPh3] (2) was determined by single-crystal X-ray diffraction, which reveals a distorted square planar geometry around the nickel(II) ion. The nitroaldol reaction was studied in detail using the nickel(II) complexes as catalysts in a homogeneous solution formed by an ionic liquid and methanol. The effect of solvent, ionic liquid, time, temperature, catalyst loading and substituent of the ligand moiety on the reaction was also studied. The β-nitroalcohol products were obtained in good yields of up to 97%. A two step substrate addition mechanism was tentatively proposed based on ESI-MS spectral monitoring of the reaction mass.