1356114-34-5

Basic information

• Product Name: 3-(2-Nitrophenoxy)oxetane
• Synonyms: 3-(2-Nitrophenoxy)oxetane
• CAS NO: 1356114-34-5
• Molecular Formula: C9H9NO4
• Molecular Weight: 195.17206
• Mol File: 1356114-34-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(2-Nitrophenoxy)oxetane(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Nitrophenoxy)oxetane(1356114-34-5)
• EPA Substance Registry System: 3-(2-Nitrophenoxy)oxetane(1356114-34-5)

Safety Data

• Hazardous Substances Data: 1356114-34-5(Hazardous Substances Data)

Upstream product

• 7748-36-9 oxetan-3-ol 
• 1493-27-2 ortho-nitrofluorobenzene 
• 88-75-5 2-hydroxynitrobenzene 

Relevant articles and documents

Enantioselective Desymmetrization of 3-Substituted Oxetanes: An Efficient Access to Chiral 3,4-Dihydro-2H-1,4-benzoxazines

Herein, we describe a versatile transition metal/oxidant free synthesis of the chiral 2H-1,4-benzoxazines through chiral phosphoric acid (CPA) catalyzed enantioselective desymmetrization of prochiral oxetanes (30 examples) in up to 99% yield and 99% enantioselectivity under mild reaction conditions. The reported strategy not only complements the conventional 2H-1,4-benzoxazine synthetic strategies but also provides access to key intermediates of therapeutic candidates, i.e., prostaglandin D2 receptor antagonist and M1 positive allosteric modulator (PAM) compound VU0486846.