135616-12-5Relevant articles and documents
Stereochemical Insights into the Anaerobic Degradation of 4-Isopropylbenzoyl-CoA in the Denitrifying Bacterium Strain pCyN1
Küppers, Julian,Becker, Patrick,Jarling, René,D?rries, Marvin,Caki?, Nevenka,Schmidtmann, Marc,Christoffers, Jens,Rabus, Ralf,Wilkes, Heinz
, p. 4722 - 4731 (2019)
The constitutions and absolute configurations of two previously unknown intermediates, (1S,2S,4S)-2-hydroxy-4-isopropylcyclohexane-1-carboxylate and (S)-3-isopropylpimelate, of anaerobic degradation of p-cymene in the bacterium Aromatoleum aromaticum pCyN
Regioselective Conversion of Cycloalkanones to Vinyl Bromide with 1,2-Functionality Transposition. A General Strategem
Paquette, Leo A.,Dahnke, Karl,Doyon, Julien,He, Wei,Wyant, Kenetha,Friedrich, Dirk
, p. 6199 - 6205 (2007/10/02)
Cyclic β-keto esters, available by regioselective acylation of cycloalkanone enolates, are rapidly transformed to α,β-unsaturated acids.This functionality transposition allows the derived 3-hydroxy-4-methylthiazole-2-(3H)-thione derivatives to serve as precursors to synthetically useful vinyl bromides.The process involves heating the hydroxamate ester with AIBN in bromotrichloromethane solution.Alkylative and ring contractive variants of the methodology are highlighted.The short sequence makes available precursors to vinyl anions that are not otherwise conveniently accessible.