1356265-83-2Relevant academic research and scientific papers
A convenient one-pot synthesis of 1-aryl-substituted 2H-isoquinolin-3-ones
Méndez, Leticia J.,Cánepa, Alicia S.,González, M. Gloria,Bravo, Rodolfo D.
experimental part, p. 688 - 690 (2012/02/15)
The synthesis of 1-aryl-substituted 2H-isoquinolin-3-ones is studied from 2-cyanomethylbenzoic acid and substituted benzenes via Friedel-Crafts acylation and intramolecular cyclization of 2-acylphenylacetonitriles formed in a one-pot method using sulfated zirconia as catalysts. Short reaction times, simplicity of operation, and easy work-up are some advantages of this method.
