135630-66-9Relevant academic research and scientific papers
Synthesis of axially dissymmetric biphenylbisphosphine ligands, BIMOPs and asymmetric hydrogenations of β-keto ester and α,β-unsaturated carboxylic acid catalyzed by their ruthenium (II) complexes
Yamamoto,Murata,Morimoto,Achiwa
, p. 1085 - 1087 (2007/10/02)
Axially dissymmetric biphenylbisphosphine ligands, BIMOP (1a) and p-MeO-BIMOP (1b) have been newly designed and prepared. The ruthenium (II) complexes of (R)-1a and 1b proved to be excellent catalysts in asymmetric hydrogenations of methyl 3-oxobutanoate and tiglic acid affording (R)-methyl 3-hydroxybutanoate of 95-99 % ee and (R)-2-methylbutyric acid of 86-91 % ee, respectively.
