1356333-53-3Relevant academic research and scientific papers
A general solid phase method for the synthesis of sequence independent peptidyl-fluoromethyl ketones
Roiban, Gheorghe-Doru,Matache, Mihaela,Hadade, Niculina D.,Funeriu, Daniel P.
, p. 4516 - 4523 (2012)
We present here a new, general, solid phase strategy for the synthesis of sequence independent peptidyl-fluoromethyl ketones using standard Fmoc peptide chemistry. Our method is based on the synthesis of bifunctional linkers which allows the incorporation of amino acid fluoromethyl ketone unit at the C-terminal end of peptide sequences. Application of this approach for the synthesis of activity based probes for SENPs is also described.
